Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type

Paul Fowler, Katie Smith, Jamie Young, +4

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Positive ResultsMedicineImmunologyCell DeathImmunophenotyping +5

Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment

Yeyejide Adeleye, Melvin E. Andersen, Rebecca A. Clewell, +13

Toxicology

Toxicity TestingToxicology TestingPrototype Risk AssessmentTranslational MedicineToxicology +17

In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop

Stefan Pfuhler, Mick D. Fellows, Jan van Benthem, +12

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

EngineeringPredictive ToxicologyMedicinePathologyGenetic Engineering +9

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. II. Importance of accurate toxicity measurement

Paul Fowler, Robert Smith, Katie Smith, +5

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Positive ResultsAccurate Toxicity MeasurementBioanalysisImmunologyToxicology Testing +6

The 3Rs as a framework to support a 21st century approach for nanosafety assessment

Natalie Burden, Karin Aschberger, Qasim Chaudhry, +7

Nano Today

21St Century ApproachEngineeringNanomaterials RegulationsToxicology TestingNanotoxicology +26

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. III: Sensitivity of human cell types to known genotoxic agents

Paul Fowler, Robert Smith, Katie Smith, +5

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Positive ResultsImmunologyToxicology TestingGenotoxic AgentsToxicology +7

Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities?

Natalie Burden, Karin Aschberger, Qasim Chaudhry, +7

Regulatory Toxicology and Pharmacology

NanoparticlesEngineeringNanomaterialsNanotechnologyNanoreactor +5

A comparison of the genotoxicity of benzo[ a ]pyrene in four cell lines with differing metabolic capacity

Ume-Kulsoom Shah, Anna L. Seager, Paul Fowler, +5

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Metabolic CapacityBiochemistryMedicineCell LinesToxicology +11

In silico approaches in carcinogenicity hazard assessment: Current status and future needs

Raymond R. Tice, Arianna Bassan, Alexander Amberg, +38

Computational Toxicology

OncologyPredictive ToxicologySilico ApproachesMedicineChemical Hazard +9

Cadmium chloride, benzo[a]pyrene and cyclophosphamide tested in the in vitro mammalian cell micronucleus test (MNvit) in the human lymphoblastoid cell line TK6 at Covance laboratories, Harrogate UK in support of OECD draft Test Guideline 487

Paul Fowler, James Whitwell, Laura Jeffrey, +3

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Harrogate UkMedicineImmunologyHematologyPathology +9