Concepedia

β1-Adrenoceptor Autoantibodies from DCM Patients Enhance the Proliferation of T Lymphocytes through the β1-AR/cAMP/PKA and p38 MAPK Pathways

Yunhui Du, Yan Li, Jin Wang, Wenzhang Zhan, Kai Song, Xue Han, Xiao Li, Ji-Min Cao, Huirong Liu

PLoS ONE · 2012 · 58 citations · 31 references

DOIFull text

Open access

Abstract

These results demonstrate that β(1)-AA isolated from DCM patients binds to β(1)-AR on the surface of T cells, causing changes in T-cell proliferation and secretion through the β(1)-AR/cAMP/PKA and p38 MAPK pathways.

References

31

Autoimmunity in idiopathic dilated cardiomyopathy. Characterization of antibodies against the beta 1-adrenoceptor with positive chronotropic effect.

Ylva Magnusson, Gerd Wallukat, Finn Waagstein et al. · Circulation · 1994 · 347 citations

Direct evidence for a β1-adrenergic receptor–directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy

Roland Jahns, Valérie Boivin, Lutz Hein et al. · Journal of Clinical Investigation · 2004 · 345 citations · Full text

Analysis and Regulation of Vasodilator-stimulated Phosphoprotein Serine 239 Phosphorylation in Vitro and in Intact Cells Using a Phosphospecific Monoclonal Antibody

Albert Smolenski, Christiane Bachmann, Kathrin Reinhard et al. · Journal of Biological Chemistry · 1998 · 335 citations · Full text

Direct evidence for a β1-adrenergic receptor–directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy

Roland Jahns, Valérie Boivin, Lutz Hein et al. · Journal of Clinical Investigation · 2004 · 308 citations · Full text

Autoantibodies Activating Human β <sub>1</sub> -Adrenergic Receptors Are Associated With Reduced Cardiac Function in Chronic Heart Failure

Roland Jahns, Valérie Boivin, Christian Siegmund et al. · Circulation · 1999 · 264 citations · Full text