The effect of sirolimus- or cyclosporine-based immunosuppression effects on T-cell subsets in vivo

The Natural History of Chronic Allograft Nephropathy

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Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

R A Seder, Ricardo T. Gazzinelli, Ali Sher et al. · Proceedings of the National Academy of Sciences · 1993 · 978 citations

Interferon Gamma Production, Adaptive Immune System, Priming Process +19

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

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Immune Cell Development, Immunology, Immunologic Mechanism +8

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

Douglas S. Robinson, Kazuko Shibuya, Alice Mui et al. · Immunity · 1997 · 723 citations · Full text

Cytokine, Immunodeficiencies, Immunology +11

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

Manuela Battaglia, Angela Stabilini, Barbara Migliavacca et al. · The Journal of Immunology · 2006 · 720 citations · Full text

Rapamycin Promotes Expansion, Healthy Subjects, T-regulatory Cell +16