The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

Nancy Hosken, Kazuko Shibuya, Andrew W. Heath, +2

The Journal of Experimental Medicine

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

Douglas S. Robinson, Kazuko Shibuya, Alice Mui, +8

Immunity

CytokineImmunodeficienciesImmunologyImmune RegulationImmunologic Mechanism +9

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

Erin Murphy, Kazuko Shibuya, Nancy Hosken, +5

The Journal of Experimental Medicine

InflammationCytokineTh2 CellsAllergyAutoimmune Disease +12

Fcα/μ receptor mediates endocytosis of IgM-coated microbes

Akira Shibuya, Norihisa Sakamoto, Yoshio Shimizu, +14

Nature Immunology

Fcα/μ ReceptorPathogenesisImmunologyEndocytic PathwayInnate Immunity +5

NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo

Tadepally Lakshmikanth, Shannon Burke, Talib Hassan Ali, +21

Journal of Clinical Investigation

Melanoma Cell LinesTumor BiologyCancer ImmunosurveillanceMedicineMelanoma +10

Accelerated tumor growth in mice deficient in DNAM-1 receptor

Akiko Iguchi‐Manaka, Hirayasu Kai, Yumi Yamashita, +7

The Journal of Experimental Medicine

CD226 (DNAM-1) Is Involved in Lymphocyte Function–associated Antigen 1 Costimulatory Signal for Naive T Cell Differentiation and Proliferation

Kazuko Shibuya, Jun Shirakawa, Tomie Kameyama, +8

The Journal of Experimental Medicine

A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory

Akiko Murayama, Kazuhisa Sakura, Mina Nakama, +10

The EMBO Journal

Epigenetic MemoryChromatinChromatin RemodelingEpigenetic ChangeGenetics +10

IL-1 alpha and TNF-alpha are required for IL-12-induced development of Th1 cells producing high levels of IFN-gamma in BALB/c but not C57BL/6 mice.

Kazuko Shibuya, Douglas S. Robinson, Francesca Zonin, +6

PubMed

Lymphocyte DevelopmentImmunologyImmune RegulationImmunologic MechanismIl-12-induced Development +18

Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor

Satoko Tahara‐Hanaoka, Kazuko Shibuya, Hirayasu Kai, +5

Blood