Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1β and prostaglandin E2 synthesis by silymarin

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

Daryl D. Rees, Selim Cellek, Richard Palmer et al. · Biochemical and Biophysical Research Communications · 1990 · 596 citations

Veterinary Medicine, Immunology, Pharmacology +16

Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.

John Hiscott, James J. Marois, Jenny Garoufalis et al. · Molecular and Cellular Biology · 1993 · 592 citations · Full text

Life Sciences, Immunology, Molecular Biology +14

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.

Charles Natanson, P. W. Eichenholz, Robert L. Danner et al. · The Journal of Experimental Medicine · 1989 · 569 citations · Full text

Veterinary Medicine, Immunology, Pathobiology +13

Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebocontrolled multicenter trial

Charles J. Fisher, Gus J. Slotman, Steven M. Opal et al. · Critical Care Medicine · 1994 · 490 citations

Medicine, Pharmacokinetics, Pharmacology +14

Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

Odette Laneuville, D.K. Breuer, David L. DeWitt et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 472 citations

Medicine, Pharmacology, Pharmacotherapy +17