The synthesis of (2S,4S,5S) -5-(N-BOC)-amino-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid lactone, an hydroxyethylene dipeptide isostere precusor

Analog approaches to the structure of the transition state in enzyme reactions

Richard Wolfenden · Accounts of Chemical Research · 1972 · 598 citations

Life Sciences, Biochemistry, Chemistry +10

A mild, general method for conversion of esters to amides

Anwer Basha, Michael F. Lipton, Steven M. Weinreb · Tetrahedron Letters · 1977 · 560 citations

Natural Sciences, Chemistry, Organic Chemistry +3

A stereocontrolled synthesis of hydroxyethylene dipeptide isosteres using novel, chiral aminoalkyl epoxides and .gamma.-(aminoalkyl)-.gamma.-lactones

B. Evans, Kenneth E. Rittle, Carl F. Homnick et al. · The Journal of Organic Chemistry · 1985 · 118 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Synthesis and biological activity of some transition-state inhibitors of human renin

Walter Fuhrer, Vittorio Rasetti, H. Rüeger et al. · Journal of Medicinal Chemistry · 1988 · 111 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

A short, stereoselective synthesis of the lactone precursor to 2R,4S,5S hydroxyethylene dipeptide isosteres

Andrew H. Fray, R. L. Kaye, Edward F. Kleinman · The Journal of Organic Chemistry · 1986 · 81 citations

Natural Sciences, Biochemistry, Chemistry +7