Pathway-Selective Sensitization of Mycobacterium tuberculosis for Target-Based Whole-Cell Screening

Genes required for mycobacterial growth defined by high density mutagenesis

Christopher M. Sassetti, Dana Boyd, Eric J. Rubin · Molecular Microbiology · 2003 · 2.6K citations · Full text

Life Sciences, Genetics, Microbiology +12

Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

John D. McKinney, Kerstin Höner zu Bentrup, Ernesto J. Muñoz‐Elías et al. · Nature · 2000 · 1.4K citations · Full text

Life Sciences, Immunology, Microbiology +9

Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries

James Inglese, Douglas S. Auld, Ajit Jadhav et al. · Proceedings of the National Academy of Sciences · 2006 · 820 citations · Full text

Pharmacy, Pharmacology, Drug Design +6

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang, S.M. Soisson, Katherine Young et al. · Nature · 2006 · 815 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

Ernesto J. Muñoz‐Elías, John D. McKinney · Nature Medicine · 2005 · 759 citations · Full text

Life Sciences, Biochemistry, Microbiology +11