Synthesis of combretastatins A-1 and B-1

A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines

Kenkichi Sonogashira, Yasuo Tohda, Nobue Hagihara · Tetrahedron Letters · 1975 · 5.1K citations

Natural Sciences, Chemistry, Catalysis +11

Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum

George R. Pettit, Sheo B. Singh, Margaret L. Niven et al. · Journal of Natural Products · 1987 · 322 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

C. Michael Lin, Sheo B. Singh, Ping S. Chu et al. · Molecular Pharmacology · 1988 · 282 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Convenient Method for the ortho-Formylation of Phenols.

Nini U. Hofsløkken, Lars Skattebøl, Fredrik Johansson et al. · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · 1999 · 201 citations · Full text

Natural Sciences, Chemistry, Organic Chemistry +2

One-step conversion of carbonyl compounds into acetylenes

Ernest W. Colvin, Brendan J. Hamill · Journal of the Chemical Society Chemical Communications · 1973 · 140 citations

Natural Sciences, Chemistry, Organic Chemistry +2