Arachidonic acid level in cellular lipids determines the amount of prostaglandins synthesized during cell growth in tissue culture

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3.1K citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +14

Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.

B B Weksler, A J Marcus, Eric Jaffe · Proceedings of the National Academy of Sciences · 1977 · 625 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

S L Hong, Lawrence Levine · Proceedings of the National Academy of Sciences · 1976 · 571 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin.

Randall M. Zusman, Harry R. Keiser · Journal of Clinical Investigation · 1977 · 355 citations · Full text

Life Sciences, Pharmacology, Physiology +13