Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Julie Thompson, Desmond G. Higgins, Toby J. Gibson · Nucleic Acids Research · 1994 · 64.9K citations · Full text

Life Sciences, Bioinformatics, Sequence Analysis +14

MRBAYES: Bayesian inference of phylogenetic trees

John P. Huelsenbeck, Fredrik Ronquist · Bioinformatics · 2001 · 22.2K citations · Full text

Life Sciences, Bioinformatics, Biology +14

CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract

Jason M. Brenchley, Timothy W. Schacker, Laura E. Ruff et al. · The Journal of Experimental Medicine · 2004 · 1.8K citations · Full text

Life Sciences, Immunology, Infectious Diseases +15

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

Harry W. Kestier, D J Ringler, Kazuyasu Mori et al. · Cell · 1991 · 1.6K citations

Life Sciences, Genetics, Molecular Biology +12

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

Joseph J. Mattapallil, Daniel C. Douek, Brenna J. Hill et al. · Nature · 2005 · 1.3K citations

Life Sciences, Immunology, Microbiology +17