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The identification of novel orally active mGluR5 antagonist GSK2210875

Maria Pilla, Michela Andreoli, Michela Tessari, Sonia Delle-Fratte, Adelheid Roth, Sharon Butler, Fiona Brown, Parita Shah, Ezio Bettini, Palmina Cavallini,

Bioorganic & Medicinal Chemistry Letters · 2010 · 25 citations · 11 references

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11

Ligand efficiency indices as guideposts for drug discovery

C ABADZAPATERO · Drug Discovery Today · 2005 · 523 citations

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Evaluation of marble-burying behavior as a model of anxiety

K. Njung'e, Sheila L. Handley · Pharmacology Biochemistry and Behavior · 1991 · 486 citations

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Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Richard H. Porter, Georg Jaeschke, Will Spooren et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 314 citations · Full text

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The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors

Adriana Pagano, Doris Rüegg, Stephane Litschig et al. · Journal of Biological Chemistry · 2000 · 268 citations · Full text

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Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists

Terry Kenakin, Stephen Jenkinson, Christian Watson · Journal of Pharmacology and Experimental Therapeutics · 2006 · 175 citations

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