Comparative and Functional Genomics · 2012 · 303 citations · 56 references
Life SciencesMolecular BiologyMolecular GeneticsGene ExpressionGene RegulationTranscriptional RegulationRna-binding ProteinsTranslation ControlTranslation RegulationTranslational ControlTranslational RegulationUntranslated Regions5' Untranslated Region RegulationCis-acting Regulatory ElementsGene Expression Modulation By Untranslated RegionsRna-binding Protein Regulation Of TranslationRna-binding Proteins In TranslationTranslational Control ElementsUntranslated Region-mediated RegulationUpstream Open Reading Frames
Translation regulation plays important roles in both normal physiological conditions and diseases states. This regulation requires cis-regulatory elements located mostly in 5' and 3' UTRs and trans-regulatory factors (e.g., RNA binding proteins (RBPs)) which recognize specific RNA features and interact with the translation machinery to modulate its activity. In this paper, we discuss important aspects of 5' UTR-mediated regulation by providing an overview of the characteristics and the function of the main elements present in this region, like uORF (upstream open reading frame), secondary structures, and RBPs binding motifs and different mechanisms of translation regulation and the impact they have on gene expression and human health when deregulated.
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The Transcriptional Landscape of the Mammalian Genome
Piero Carninci, Takeya Kasukawa, Shintaro Katayama et al. · Science · 2005 · 3.6K citations