Concepedia

Rational quantitative structure–activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands

Ann M. Dring, Linnea E. Anderson, Saima Qamar, Matthew Stoner

Chemico-Biological Interactions · 2010 · 43 citations · 38 references

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38

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

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Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

Linda B. Moore, Derek J. Parks, Stacey A. Jones et al. · Journal of Biological Chemistry · 2000 · 810 citations · Full text

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The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

Tatsuya Sueyoshi, Takeshi Kawamoto, Igor N. Zelko et al. · Journal of Biological Chemistry · 1999 · 671 citations · Full text

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Structural Features of Alkylphenolic Chemicals Associated with Estrogenic Activity

Edwin J. Routledge, John P. Sumpter · Journal of Biological Chemistry · 1997 · 495 citations · Full text

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.

Myriam Baes, T Gulick, Hueng-Sik Choi et al. · Molecular and Cellular Biology · 1994 · 469 citations · Full text

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