Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

Stéphane Heymans, Aernout Luttun, Dieter Nuyens, +20

Nature Medicine

CardiomyopathyHeart FailureCardiovascular DiseasePlasminogen ActivatorsMedicine +9

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

Peter Carmeliet, Lieve Moons, Roger Lijnen, +8

Nature Genetics

InflammationUrokinase-generated PlasminMetalloproteinEndothelial DysfunctionVascular Biology +5

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Sandra Schoors, Ulrike Brüning, Rindert Missiaen, +21

Nature

AngiogenesisFatty Acid CarbonBiochemistryEndothelial CellsNatural Sciences +9

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Julián Aragonés, Martin Schneider, Katie Van Geyte, +43

Nature Genetics

BiochemistryRedox RegulatorPhysiologyHypoxia ToleranceHypoxia (Medicine) +7

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.

Myriam Baes, T Gulick, Hueng-Sik Choi, +3

Molecular and Cellular Biology

Molecular RegulationMolecular BiologyRetinoic Acid ResponseNew Orphan MemberCell Signaling +16

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes

Celia M. Kassmann, Corinna Lappe-Siefke, Myriam Baes, +8

Nature Genetics

Neurodegenerative DiseasesMolecular NeuroscienceMedicineAxonal LossNeurology +6

A mouse model for Zellweger syndrome

Myriam Baes, Pierre Gressèns, Eveline Baumgart‐Vogt, +9

Nature Genetics

Knockout MouseDevelopmental BiologyPathologyDegenerative DiseaseMedicine +1

Mitochondrial Alterations Caused by Defective Peroxisomal Biogenesis in a Mouse Model for Zellweger Syndrome (PEX5 Knockout Mouse)

Eveline Baumgart‐Vogt, Ilse Vanhorebeek, Markus Grabenbauer, +3

American Journal Of Pathology

Knockout MouseMitophagyMitochondrial AlterationsMitochondrial BiogenesisMitochondrial Function +10

Inactivation of the Peroxisomal Multifunctional Protein-2 in Mice Impedes the Degradation of Not Only 2-Methyl-branched Fatty Acids and Bile Acid Intermediates but Also of Very Long Chain Fatty Acids

Myriam Baes, Steven Huyghe, Peter Carmeliet, +4

Journal of Biological Chemistry

Lipid PeroxidationMfp-2 Knockout MiceMfp-2 DeficiencyRedox BiologyOxidative Stress +15

Identification and Characterization of the Putative Human Peroxisomal C-terminal Targeting Signal Import Receptor

Marc Fransen, Chantal Brees, Eveline Baumgart‐Vogt, +4

Journal of Biological Chemistry