Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor

Evaluation of Various Dissolution Media for Predicting In Vivo Performance of Class I and II Drugs

Eric Galia, Eleftheria Nicolaides, D. Hörter et al. · Pharmaceutical Research · 1998 · 923 citations

Pharmacy, Pharmaceutics, Pharmacology +16

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Iain P. Chessell, Jonathan P. Hatcher, C. Bountra et al. · Pain · 2005 · 784 citations

Life Sciences, Immunology, Neurobiology +17

Tissue distribution of the P2X7 receptor

Ginetta Collo, S. Neidhart, Eric Kawashima et al. · Neuropharmacology · 1997 · 498 citations

Medicine, Neuroscience, Pharmacology +13

A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

Prisca Honoré, Diana L. Donnelly‐Roberts, Marian T. Namovic et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 409 citations

Medicine, Neuroscience, Pharmacology +17

Evaluation of the MDR-MDCK cell line as a permeability screen for the blood–brain barrier

Qing Wang, Joseph Rager, Kathryn E. Weinstein et al. · International Journal of Pharmaceutics · 2004 · 345 citations

Medicine, Cell Biology, Pharmacology +9