Concepedia

Brain-Derived Neurotrophic Factor Gene Transfer With Adeno-Associated Viral and Lentiviral Vectors Prevents Rubrospinal Neuronal Atrophy and Stimulates Regeneration-Associated Gene Expression After Acute Cervical Spinal Cord Injury

Brian K. Kwon, Jie Liu, Clarrie K. Lam, Ward T. Plunet, Loren W. Oschipok, William W. Hauswirth, Adriana Di Polo, Armin Blesch, Wolfram Tetzlaff

Spine · 2007 · 79 citations · 25 references

DOI

Abstract

Viral-mediated transfer of the BDNF gene was successful at promoting a regenerative response in rubrospinal neurons following acute cervical spinal cord injury, with significantly less parenchymal damage than previously observed when infusing the BDNF protein.

References

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