BDNF and NT-4/5 Prevent Atrophy of Rat Rubrospinal Neurons after Cervical Axotomy, Stimulate GAP-43 and Tα1-Tubulin mRNA Expression, and Promote Axonal Regeneration

Nao Kobayashi, Da-Peng Fan, Klaus M. Giehl, +3

Journal of Neuroscience

Peripheral Nerve InjuryMarked AtrophyStimulate Gap-43Peripheral NerveDelayed Atrophy +18

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

Pernille Jansen, Klaus M. Giehl, Jens Randel Nyengaard, +11

Nature Neuroscience

NeuroregenerationDevelopmental BiologyBrain DevelopmentMedicineSocial Sciences +10

Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury

Anthony Harrington, Britta Leiner, C. Blechschmitt, +7

Proceedings of the National Academy of Sciences

BDNF and NT‐3, but not NGF, Prevent Axotomy‐induced Death of Rat Corticospinal Neurons <i>In Vivo</i>

Klaus M. Giehl, Wolfram Tetzlaff

European Journal of Neuroscience

Peripheral Nerve InjuryCell DeathSevere AtrophyNeuroinflammationNeuronal Atrophy +16

Alternative Splicing Switches the Divalent Cation Selectivity of TRPM3 Channels

Johannes Oberwinkler, Annette Lis, Klaus M. Giehl, +2

Journal of Biological Chemistry

Signal TransductionMolecular PhysiologyG Protein-coupled ReceptorCell SignalingMembrane Transport +13

Posttraumatic GABAA-Mediated [Ca2+]i Increase Is Essential for the Induction of Brain-Derived Neurotrophic Factor-Dependent Survival of Mature Central Neurons

Anastasia Shulga, Judith Thomas-Crusells, T. Sigl, +7

Journal of Neuroscience

Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity

Uwe Beffert, Andre Durudas, Edwin J. Weeber, +5

Journal of Neuroscience

Nfdnpvy SequenceCytoskeletonSynaptic SignalingSignaling PathwayReceptor Tyrosine Kinase +14

Endogenous Brain-Derived Neurotrophic Factor and Neurotrophin-3 Antagonistically Regulate Survival of Axotomized Corticospinal Neurons<i>In Vivo</i>

Klaus M. Giehl, Stephan Röhrig, Henk Bonatz, +10

Journal of Neuroscience

Tyrosine KinaseApoptosisImmunologyCell DeathPeripheral Nerves +18

The survival-promoting effect of glial cell line-derived neurotrophic factor on axotomized corticospinal neurons in vivo is mediated by an endogenous brain-derived neurotrophic factor mechanism.

Klaus M. Giehl, Andreas Schütte, P. Mestres, +1

PubMed

Survival-promoting EffectAxotomized Corticospinal NeuronsCellular NeurobiologySocial SciencesNeuroinflammation +16

ApoE Receptor 2 Controls Neuronal Survival in the Adult Brain

Uwe Beffert, Farnas Nematollah Farsian, Irene Masiulis, +4

Current Biology

NeurophysiologyPhysiologyNeuropharmacologyApoe Receptor 2Neuroprotection +5