X-ray Structure of Citrate Bound to Src SH2 Leads to a High-Affinity, Bone-Targeted Src SH2 Inhibitor

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTX-ray Structure of Citrate Bound to Src SH2 Leads to a High-Affinity, Bone-Targeted Src SH2 InhibitorRegine S. Bohacek, David C. Dalgarno, Marcos Hatada, Virginia A. Jacobsen, Berkley A. Lynch, Karina J. Macek, Taylor Merry, Chester A. Metcalf, Surinder S. Narula, Tomi K. Sawyer, William C. Shakespeare, Shelia M. Violette, and Manfred WeigeleView Author Information ARIAD Pharmaceuticals, Inc., 26 Landsdowne Street, Cambridge, Massachusetts 02139-4234 Cite this: J. Med. Chem. 2001, 44, 5, 660–663Publication Date (Web):February 6, 2001Publication History Received22 June 2000Published online6 February 2001Published inissue 1 March 2001https://pubs.acs.org/doi/10.1021/jm0002681https://doi.org/10.1021/jm0002681rapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views543Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Crystal structure,Ligands,Noncovalent interactions,Peptides and proteins,Screening assays Get e-Alerts