A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

Philippe Soriano, Charles A. Montgomery, Robert S. Geske et al. · Cell · 1991 · 2K citations

Medicine, Molecular Biology, Oncology +12

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

Jeffrey H. Hanke, Joseph P. Gardner, Robert L. Dow et al. · Journal of Biological Chemistry · 1996 · 2K citations · Full text

Life Sciences, Immunology, Pharmacology +17

Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.

A. M. Parfitt, Catharina H. E. Mathews, A. R. Villanueva et al. · Journal of Clinical Investigation · 1983 · 1.5K citations · Full text

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17

Three-dimensional structure of the tyrosine kinase c-Src

Wenqing Xu, Stephen C. Harrison, Michael J. Eck · Nature · 1997 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +14

Principles of Bone Biology

Juliet Compston · Clinical Endocrinology · 1997 · 1.4K citations

Medicine, Anatomy, Orthopaedic Surgery +12