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A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo

SclerostinSignal TransductionOrthopaedic SurgeryTyrosine Kinase SrcMedicineBone Morphogenic ProteinRodent ModelsOsteoarthritisOsteoporosisBone HomeostasisReduces BoneCell BiologyCell SignalingBone MetabolismOsteocalcin