Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon

SOCS3 negatively regulates IL-6 signaling in vivo

Ben A. Croker, Danielle L. Krebs, Jian‐Guo Zhang et al. · Nature Immunology · 2003 · 844 citations

Life Sciences, Cell Biology, Immunology +10

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

Hideo Yasukawa, Masanobu Ohishi, Hiroyuki Mori et al. · Nature Immunology · 2003 · 779 citations

Life Sciences, Cell Biology, Immunology +14

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

Christoph Becker, Massimo Claudio Fantini, Christoph Schramm et al. · Immunity · 2004 · 719 citations · Full text

Medicine, Immunology, Oncology +16

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

Zhi Chen, Arian Laurence, Yuka Kanno et al. · Proceedings of the National Academy of Sciences · 2006 · 640 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation

Asuka Suzuki, Toshikatsu Hanada, Keiichi Mitsuyama et al. · The Journal of Experimental Medicine · 2001 · 477 citations · Full text

Life Sciences, Immunology, Pathology +17