Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels

An essential role for free radicals and derived species in signal transduction

Harry M. Lander · The FASEB Journal · 1997 · 901 citations

Radical Emission, Lipid Peroxidation, Molecular Biology +20

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Marcello Trevisani, Jan Siemens, Serena Materazzi et al. · Proceedings of the National Academy of Sciences · 2007 · 753 citations · Full text

Pain Medicine, Immunology, Neuropathic Pain +22

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

David A. Andersson, Clive Gentry, Sian Moss et al. · Journal of Neuroscience · 2008 · 702 citations · Full text

TRPA1 is a major oxidant sensor in murine airway sensory neurons

Bret F. Bessac, Michael Sivula, Christian A. von Hehn et al. · Journal of Clinical Investigation · 2008 · 442 citations · Full text

Lung Inflammation, Redox Biology, Cellular Physiology +17

Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain

Hee Kee Kim, Soon Kwon Park, Jun-Li Zhou et al. · Pain · 2004 · 440 citations

Pain Medicine, Neuropathic Pain, Molecular Pain +19