Concepedia

Inhibition of colonic motility and defecation by RS‐127445 suggests an involvement of the 5‐HT<sub>2B</sub> receptor in rodent large bowel physiology

AK Bassil, VJN Bolton, KM Gray, J.D. Brown, Leanne Cutler, SG Summerfield, Gordon Bruton, W. Winchester, K. Lee

British Journal of Pharmacology · 2009 · 21 citations · 17 references

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Abstract

High-protein binding of RS-127445 indicates that relatively high doses are required for efficacy. The results suggest that 5-HT(2B) receptors tonically regulate colonic motility.

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