The role of thrombin receptors PAR1 and PAR4 for PAI-1 storage, synthesis and secretion by human platelets

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

Anders Hamsten, Björn Wiman, Ulf dé Fairé et al. · New England Journal of Medicine · 1985 · 1.4K citations

Medicine, Cardiology, Clinical Cardiology +10

Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet α granules and differentially released

Joseph E. Italiano, Jennifer L. Richardson, Sunita Patel–Hett et al. · Blood · 2007 · 845 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study

T MEADE · The Lancet · 1993 · 714 citations

Medicine, Cardiology, Internal Medicine +12

Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis

Stephan Lindemann, Neal D. Tolley, Dan A. Dixon et al. · The Journal of Cell Biology · 2001 · 690 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay

Margot F. K. Verstreken, EK Kruithof, I. Juhan‐Vague et al. · Blood · 1988 · 532 citations · Full text

Pharmacy, Immunology, Immunotechnology +8