The effect of iodine position on uptake in the mouse using an isomeric series of 2‐deoxy‐2‐O‐([¹²³I]‐iodobenzyl)glucoses

Abstract

Abstract The ortho, meta and para iodinated series of 2‐deoxy‐2‐O‐(iodobenzyl)glucose (IBG) were prepared by addition of the desired iodobenzyl bromide with 3,4,6‐tri‐O‐acetyl‐piperidine‐N‐D‐glucose. Subsequent exchange labelling with [ 123 I]NaI enabled their biodistribution to be studied in mice. The lipophilicity of each compound was measured by their octanol:water partition coefficients, showing the meta‐ and para‐IBG to be more lipophilic than ortho‐IBG. Examination of the biodistribution data suggests that there is a correlation between tissue uptake and iodine position(lipophilicity).