Antimalarial Drug Artemisinin Extenuates Amyloidogenesis and Neuroinflammation in <scp>APP</scp>swe/<scp>PS</scp>1dE9 Transgenic Mice via Inhibition of Nuclear Factor‐κ<scp>B</scp> and <scp>NLRP</scp>3 Inflammasome Activation

Abstract

The in vivo study clearly demonstrates that artemisinin has protective effects on AD pathology due to its effects on suppressing NF-κB activity and NALP3 inflammasome activation. Our study suggests that targeting NF-κB activity and NALP3 inflammasome activation offers a valuable intervention for AD.