Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones

New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay

John M. Domagala, Lori Doyle Hanna, Carl L. Heifetz et al. · Journal of Medicinal Chemistry · 1986 · 265 citations

The new generation of quinolones

Comparative Biochemistry and Physiology Part A Physiology · 1991 · 96 citations

Pharmacology, New Generation, Antimicrobial Chemotherapy +1

Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents

Tuan P. Tran, Edmund L. Ellsworth, Michael A. Stier et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 75 citations

Antimicrobial Drug Discovery, Medicine, Antibacterial Agent +3

In Vitro and In Vivo Activities of PD 0305970 and PD 0326448, New Bacterial Gyrase/Topoisomerase Inhibitors with Potent Antibacterial Activities versus Multidrug-Resistant Gram-Positive and Fastidious Organism Groups

Michael D. Huband, Michael Cohen, Margaret Zurack et al. · Antimicrobial Agents and Chemotherapy · 2007 · 74 citations · Full text

Pd 0326448, S. Pneumoniae, Antimicrobial Chemotherapy +17

3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms

Edmund L. Ellsworth, Tuan P. Tran, Hollis D. Showalter et al. · Journal of Medicinal Chemistry · 2006 · 62 citations · Full text

Bioorganic Chemistry, Antiparasitic Agent, Antibiotic Adjuvant +19