High-Level Production and Purification of P30P2MSP119, an Important Vaccine Antigen for Malaria, Expressed in the Methylotropic Yeast Pichia pastoris

A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.

Michael J. Blackman, H. G. Heidrich, Stuart P. Donachie et al. · The Journal of Experimental Medicine · 1990 · 560 citations · Full text

Veterinary Medicine, Immunology, Molecular Biology +15

Proteolytic processing of thePlasmodium falciparum merozoite surface protein-1 produces a membrane-bound fragment containing two epidermal growth factor-like domains

Michael J. Blackman, Irene T. Ling, Stephen C. Nicholls et al. · Molecular and Biochemical Parasitology · 1991 · 235 citations

Life Sciences, Biochemistry, Molecular Biology +13

ModelingPichia pastoris growth on methanol and optimizing the production of a recombinant protein, the heavy-chain fragment C of botulinum neurotoxin, serotype A

Wenhui Zhang, Mark A. Bevins, Bradley A. Plantz et al. · Biotechnology and Bioengineering · 2000 · 234 citations

Life Sciences, Biotechnology, Microbiology +17

Immunogenicity and In Vivo Efficacy of Recombinant Plasmodium falciparum Merozoite Surface Protein-1 in Aotus Monkeys

Sanjai Kumar, Anjali Yadava, David B. Keister et al. · Molecular Medicine · 1995 · 187 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17

A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmodium yoelii yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice

T M Daly, Carole A. Long · Infection and Immunity · 1993 · 183 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17