Concepedia

Imipramine N-Glucuronidation in Human Liver Microsomes: Biphasic Kinetics and Characterization of UDP-Glucuronosyltransferase Isoforms

Miki Nakajima, Eriko Tanaka, Tomo Kobayashi, Noriko Ohashi, Toshiyuki Kume, Tsuyoshi Yokoi

Drug Metabolism and Disposition · 2002 · 67 citations · 21 references

DOI

Concepts

References

21

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

Piter J. Bosma, Jurgen Seppen, Bart Goldhoorn et al. · Journal of Biological Chemistry · 1994 · 449 citations · Full text

, , +11

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus

Jeong W. Cho, Theresa Huang, Christine Potter et al. · Pharmacogenetics · 2001 · 272 citations

, , +11

Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3.

Mitchell D. Green, Christopher D. King, B. Mojarrabi et al. · PubMed · 1998 · 258 citations

, , +9

Polymorphic Gene Regulation and Interindividual Variation of UDP-glucuronosyltransferase Activity in Human Small Intestine

Christian P. Strassburg, Susanne Kneip, Juliane Topp et al. · Journal of Biological Chemistry · 2000 · 252 citations · Full text

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Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation

Sahidan Senafi, Douglas J. Clarke, Brian Burchell · Biochemical Journal · 1994 · 242 citations · Full text

, , +16