The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

Lydiane Pichard, Isabelle Fabre, Gérard Fabre et al. · Drug Metabolism and Disposition · 1990 · 437 citations

Medicine, Pharmacology, Toxicology +17

Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

Partha Pratim Roy, L J Yu, Charles L. Crespi et al. · Drug Metabolism and Disposition · 1999 · 319 citations

Medicine, Biochemistry, Pharmacology +17

Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450

Dominique Diaz, Isabelle Fabrev, Martine Daujat‐Chavanieu et al. · Gastroenterology · 1990 · 311 citations

Medicine, Pharmacokinetics, Pharmacology +14

Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

Dorothea Sesardic, B. P. Murray, Sandra Murray et al. · British Journal of Clinical Pharmacology · 1990 · 280 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17