Concepedia

Upregulation of Immunoproteasome Subunits in Myositis Indicates Active Inflammation with Involvement of Antigen Presenting Cells, CD8 T-Cells and IFNγ

Khetam Ghannam, Lorena Martinez‐Gamboa, Lydia Spengler, Sabine Krause, Biljana Smiljanovic, Marc Bonin, Salyan Bhattarai, Andreas Grützkau, G.-R. Burmester, Thomas Häupl,

PLoS ONE · 2014 · 44 citations · 38 references

DOIFull text

Open access

Abstract

Immunoproteasomes seem to indicate IIM activity and suggest that dominant involvement of antigen processing and presentation may qualify these diseases exemplarily for the evolving therapeutic concepts of immunoproteasome specific inhibition.

References

38

A new mathematical model for relative quantification in real-time RT-PCR

Michael W. Pfaffl · Nucleic Acids Research · 2001 · 34.3K citations · Full text

Structure of 20S proteasome from yeast at 2.4Å resolution

M. Groll, Lars Ditzel, Jan Löwe et al. · Nature · 1997 · 2.2K citations

, , +5

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Tony Muchamuel, Michael Basler, Monette Aujay et al. · Nature Medicine · 2009 · 590 citations

, , +12

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

Ulrike Seifert, Frédéric Ebstein, Dawadschargal Bech‐Otschir et al. · Cell · 2010 · 537 citations · Full text

, , +7

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

E.M. Huber, Michael Basler, Ricarda Schwab et al. · Cell · 2012 · 488 citations · Full text

, , +9