Activating gene expression in mammalian cells with promoter-targeted duplex RNAs

Active genes are tri-methylated at K4 of histone H3

Helena Santos-Rosa, Robert Schneider, Andrew J. Bannister et al. · Nature · 2002 · 2.1K citations

Histone Modifications, Chromatin, Active Genes +11

Rational siRNA design for RNA interference

Angela Reynolds, Devin Leake, Queta Boese et al. · Nature Biotechnology · 2004 · 2.1K citations

Rational Sirna Design, Natural Sciences, Rna Biology +7

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

Philippe Kastner, A. Krust, Bernard Turcotte et al. · The EMBO Journal · 1990 · 1.5K citations · Full text

Distinct Estrogen-regulated Promoters, Systems Biology, Molecular Physiology +10

RNA-directed de novo methylation of genomic sequences in plants

Michael Wassenegger, Sabine Heimes, Leonhard Riedel et al. · Cell · 1994 · 924 citations

Biology, Plant Genetics, Genetics +5

Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells

Kevin V. Morris, Wan Chan, Steven E. Jacobsen et al. · Science · 2004 · 919 citations

Transcriptional Regulation, Systems Biology, Engineering +13