Activating gene expression in mammalian cells with promoter-targeted duplex RNAs

Bethany A. Janowski, Scott T. Younger, Daniel B. Hardy, +3

Nature Chemical Biology

Transcriptional RegulationEngineeringRna BiologyGene RegulationGene Transcription +6

Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display

David M Shechner, Ezgi Hacisuleyman, Scott T. Younger, +1

Nature Methods

GeneticsGene EditingGenome EditingOff-target EffectMedicine +2

Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens

Fadi J. Najm, Christine Strand, Katherine Donovan, +12

Nature Biotechnology

GeneticsGenetic EngineeringMolecular BiologyMolecular GeneticsGene Editing +4

Antisense transcripts are targets for activating small RNAs

Jacob C. Schwartz, Scott T. Younger, Ngoc-Bich Nguyen, +4

Nature Structural & Molecular Biology

Transcriptional RegulationAntisense TranscriptsRna BiologySmall RnaGene Expression +3

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

Joshua M. Dempster, Clare Pacini, Sasha Pantel, +21

Nature Communications

Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters

Scott T. Younger, David R. Corey

Nucleic Acids Research

Histone ModificationsGeneticsGene PromoterGene TranscriptionEpigenetics +16

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

Isaac S. Harris, Jennifer E. Endress, Jonathan L. Coloff, +18

Cell Metabolism

Reductive StressBiochemistryMedicineGlutathione DepletionCancer Cells +7

Cells Lacking the <i>RB1</i> Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

Matthew G. Oser, Raquel Fonseca, Abhishek A. Chakraborty, +26

Cancer Discovery

Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter

Yongjun Chu, Yue Xuan, Scott T. Younger, +2

Nucleic Acids Research

Transcriptional regulation by small RNAs at sequences downstream from 3′ gene termini

Yue Xuan, Jacob C. Schwartz, Yongjun Chu, +5

Nature Chemical Biology

Rna ProcessingTranscriptional RegulationSystems BiologyDevelopmental BiologyEngineering +8