Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four-week study in cynomolgus monkeys

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

Louis C. Bock, Linda C. Griffin, John Latham et al. · Nature · 1992 · 2.5K citations

Medicine, Biotechnology, Molecular Biology +13

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.

K. Padmanabhan, K. Padmanabhan, Joseph D. Ferrara et al. · Journal of Biological Chemistry · 1993 · 462 citations · Full text

Medicine, Molecular Biology, Hemostasis +13

THE STRUCTURE OF ALPHA-THROMBIN INHIBITED BY A 15-MER SINGLE-STRANDED DNA APTAMER

K. Padmanabhan, K. Padmanabhan, Joseph D. Ferrara et al. · 1993 · 427 citations

Life Sciences, Chemical Biology, Molecular Biology +10

In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits

LC Griffin, GF Tidmarsh, LC Bock et al. · Blood · 1993 · 278 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14

Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides.

C. Frank Bennett, Thomas P. Condon, S Grimm et al. · The Journal of Immunology · 1994 · 253 citations

Life Sciences, Cell Biology, Molecular Biology +17