The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.

Abstract

forms of thrombin -9 Glu and Lys149E + Ala)' (Wu et al., 1992).The results with the Arg75 -+ Glu mutant suggest that the DNA binding site is located in the thrombin fibrinogen recognition exosite and overlaps the thrombin platelet receptor and thrombomodulin binding sites.