Concepedia

A Convergent Total Synthesis of Calicheamicin γ

Stephen A. Hitchcock, Serge H. Boyer, Margaret Y. Chu‐Moyer, Steven H. Olson, Samuel J. Danishefsky

Angewandte Chemie International Edition in English · 1994 · 70 citations · 30 references

DOI

Concepts

Abstract

Ultimate convergence for the total synthesis of calicheamicin γ has been achieved thanks to a remarkable glycosidation between the glycosyl donor 2 and aglycone ent-1 (see preceeding communication; R = SSMe, ketal-protected); after glycosidation the natural product is obtained in two steps.

References

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Total synthesis of calicheamicin .gamma.1I

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