P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David Borchelt, Gopal Thinakaran, Christopher B. Eckman et al. · Neuron · 1996 · 1.5K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

David Borchelt, Tamara Ratovitski, Judy van Lare et al. · Neuron · 1997 · 1K citations

Life Sciences, Neurology, Neuroscience +17

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

Kuo‐Fen Lee, En Li, L. Julie Huber et al. · Cell · 1992 · 962 citations

Medicine, Neurobiology, Neuroscience +14

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

Jie Shen, Roderick T. Bronson, Dongfeng Chen et al. · Cell · 1997 · 957 citations · Full text

Life Sciences, Genetics, Neuroscience +10