Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

James R. Bischoff, David H. Kirn, Angelica Williams et al. · Science · 1996 · 1.8K citations

Mutant Adenovirus, Adenovirus Mutant, Functional P53 +13

A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

Gareth L. Bond, Wenwei Hu, Elisabeth E. Bond et al. · Cell · 2004 · 1.3K citations · Full text

Mdm2 Promoter, Single Nucleotide Polymorphism, Oncogenic Agent +10

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

Carla Heise, Adam Sampson-Johannes, Angelica Williams et al. · Nature Medicine · 1997 · 944 citations

Tumor Biology, Cancer-associated Virus, Oncogenic Agent +10

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

M Debbas, Eileen White · Genes & Development · 1993 · 876 citations · Full text

Cancer Research, Systems Biology, Cell Regulation +13

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

Nicholas C. Jones, Thomas Shenk · Cell · 1979 · 785 citations

Rat Embryo Cells, Viral Replication, Developmental Biology +10