Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Martin Holzenberger, Joëlle Dupont, Bertrand Ducos et al. · Nature · 2002 · 2.1K citations · Full text

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Suppression of Aging in Mice by the Hormone Klotho

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A Mutant <i>Drosophila</i> Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

Marc Tatar, A. H. Kopelman, Diane Epstein et al. · Science · 2001 · 1.6K citations

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Extension of Life-Span by Loss of CHICO, a <i>Drosophila</i> Insulin Receptor Substrate Protein

David J. Clancy, David Gems, Lawrence G. Harshman et al. · Science · 2001 · 1.4K citations

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