Insulin Biosynthesis is a biochemical process in which the hormone insulin is synthesized as a preprohormone in pancreatic beta cells through a series of post-translational modifications including proteolytic cleavage to yield the mature, biologically active insulin dimer.
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Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
Maryam Asfari, D. Janjic, P. Mêda et al. · Endocrinology · 1992 · 1.1K citations · Full text
Insulin Biosynthesis: Evidence for a Precursor
Donald F. Steiner, Dennis D. Cunningham, Lilian Spigelman et al. · Science · 1967 · 708 citations
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Howard Hughes Medical Institute
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