Functional heterogeneity of CD4-positive T-cell subsets: The correlation between effector functions and lymphokine secretion is limited

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

Life Sciences, Cell Biology, Apoptosis +14

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

Clifford M. Snapper, William E. Paul · Science · 1987 · 1.9K citations

Life Sciences, Cell Biology, Immunology +17

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

Frederick P. Heinzel, M D Sadick, B J Holaday et al. · The Journal of Experimental Medicine · 1989 · 1.5K citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

Holly Cherwinski, J H Schumacher, Kenneth D. Brown et al. · The Journal of Experimental Medicine · 1987 · 1K citations · Full text

Life Sciences, Immunology, Molecular Biology +14

The isolation and characterization of the human suppressor inducer T cell subset.

Chikao Morimoto, Norman L. Letvin, J A Distaso et al. · The Journal of Immunology · 1985 · 856 citations · Full text

Life Sciences, Cell Biology, Immunology +10