Bolus Intravenous Injection of Phosphorothioate Oligonucleotides Causes Hypotension by Acting as α1-Adrenergic Receptor Antagonists

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

Life Sciences, Microbiology, Molecular Biology +10

Beta Adrenergic Receptor Binding in Membrane Preparations from Mammalian Brain

David B. Bylund, Solomon H. Snyder · Molecular Pharmacology · 1976 · 574 citations · Full text

Medicine, Neurobiology, Pharmacology +16

The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism.

Teresa L. Burgess, Eric F. Fisher, Sandra L. Ross et al. · Proceedings of the National Academy of Sciences · 1995 · 322 citations · Full text

Medicine, Molecular Biology, Pharmacology +16

Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury.

Yi Shi, Ali Fard, A Galeo et al. · Circulation · 1994 · 238 citations · Full text

Medicine, Cardiology, Pharmacology +13