The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

Jiping Zha, Hisashi Harada, Elizabeth Yang et al. · Cell · 1996 · 2.6K citations · Full text

Life Sciences, Cell Biology, Apoptosis +15

Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412

Richard M. Stone, Daniel J. DeAngelo, Virginia M. Klimek et al. · Blood · 2004 · 660 citations · Full text

Medicine, Molecular Genetics, Oncology +14

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412

Ellen Weisberg, Christina Boulton, Louise Kelly et al. · Cancer Cell · 2002 · 602 citations · Full text

Medicine, Oncology, Pharmacology +14

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

Antonia Lopez‐Girona, Beth Furnari, Odile Mondesert et al. · Nature · 1999 · 581 citations

Life Sciences, Cell Biology, Molecular Biology +16

Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells

Stewart D. Lyman, L James, Tim Vanden Bos et al. · Cell · 1993 · 541 citations

Life Sciences, Hematology, Molecular Biology +17