Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

Erik W. Thompson, Soonmyoung Paik, Nils Brünner et al. · Journal of Cellular Physiology · 1992 · 525 citations

Medicine, Cell Biology, Oncology +13

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

Rama Khokha, Paul Waterhouse, Simcha Yagel et al. · Science · 1989 · 457 citations

Medicine, Cancer Biology, Oncology +10

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

Paul Säftig, Michal Hetman, Wolfgang W. Schmahl et al. · The EMBO Journal · 1995 · 442 citations · Full text

Medicine, Pathobiology, Pathology +17

Cloning and sequence analysis of cDNA for human cathepsin D.

Phyllis L. Faust, Stuart Kornfeld, John M. Chirgwin · Proceedings of the National Academy of Sciences · 1985 · 320 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

FRANCHISE VIGNON, FRANQOISE CAPONY, MONIQUE GHAMBON et al. · Endocrinology · 1986 · 273 citations

Life Sciences, Biochemistry, Endocrinology +13