Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT

Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system

D. Subhas Bose, Andrew S. Thompson, Jingshan Ching et al. · Journal of the American Chemical Society · 1992 · 136 citations

Engineering, Dna Analysis, Altmetric Attention Score +22

Self-Immolative Prodrugs: Candidates for Antibody-Directed Enzyme Prodrug Therapy in Conjunction with a Nitroreductase Enzyme

Anthony B. Mauger, Philip J. Burke, Hanif H. Somani et al. · Journal of Medicinal Chemistry · 1994 · 114 citations

Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-<i>c</i>][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents

David E. Thurston, D. Subhas Bose, Andrew S. Thompson et al. · The Journal of Organic Chemistry · 1996 · 114 citations

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +11

Synthesis and identification of the major metabolites of prazosin formed in dog and rat

T. H. ALTHUIS, H Hess · Journal of Medicinal Chemistry · 1977 · 77 citations

Medicinal Chemistry, Pharmacological Study, Biochemistry +12

Effect of linker length on DNA-binding affinity, cross-linking efficiency and cytotoxicity of C8-linked pyrrolobenzodiazepine dimers

D. Subhas Bose, Andrew S. Thompson, M Smellie et al. · Journal of the Chemical Society Chemical Communications · 1992 · 73 citations

Combinatorial Chemistry, Cross-linking Efficiency, Medicinal Chemistry +15