Intranodal Administration of Peptide-Pulsed Mature Dendritic Cell Vaccines Results in Superior CD8⁺T-Cell Function in Melanoma Patients

Abstract

Administration of this peptide-pulsed mature DC vaccine by IN, IV, or ID routes is feasible and safe. IN administration seems to result in superior T-cell sensitization as measured by de novo target-cell recognition and DTH priming, indicating that IN may be the preferred ROA for mature DC vaccines.