Publication | Closed Access
Structure−Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC)
259
Citations
9
References
2010
Year
Drug TargetClinical CandidatePharmacotherapyChemical BiologyPharmaceutical ChemistryMolecular PharmacologyMedicinal ChemistryStructure-activity Relationship StudyAnti-cancer AgentBiochemistryCastration-resistant Prostate CancerProstatic DiseaseDrug DevelopmentPharmacologyMolecular ModelingStructure−activity RelationshipAnalogues 14Natural SciencesRational Drug DesignMedicineDrug Discovery
A structure-activity relationship study was carried out on a series of thiohydantoins and their analogues 14 which led to the discovery of 92 (MDV3100) as the clinical candidate for the treatment of hormone refractory prostate cancer.
| Year | Citations | |
|---|---|---|
Page 1
Page 1