Concepedia

Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors

John Porter, Andrew Payne, Ben de Candole, Daniel Ford, Brian Hutchinson, Graham Trevitt, James M. A. Turner, Chloe Edwards, Clare Watkins, Ian Whitcombe,

Bioorganic & Medicinal Chemistry Letters · 2008 · 123 citations · 13 references

DOIFull text

Open access

Concepts

References

13

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker et al. · Nature · 2005 · 3.4K citations

, , +14

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

Christin Tse, Alexander R. Shoemaker, Jessica Adickes et al. · Cancer Research · 2008 · 2K citations · Full text

, , +16

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

Steven W. Muchmore, Michael Sattler, Heng Liang et al. · Nature · 1996 · 1.5K citations

, , +11

Structure of Bcl-x <sub>L</sub> -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

Michael Sattler, Heng Liang, David G. Nettesheim et al. · Science · 1997 · 1.5K citations

, , +17

Solution structure of the antiapoptotic protein bcl-2

Andrew M. Petros, A Medek, David G. Nettesheim et al. · Proceedings of the National Academy of Sciences · 2001 · 454 citations · Full text

, , +15