Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

Koenraad Gijbels, Richard E. Galardy, Lawrence Steinman · Journal of Clinical Investigation · 1994 · 341 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

Charles Pyke, Pirkko Huhtala, T Hurskainen et al. · PubMed · 1992 · 329 citations

Medicine, Oncology, Pathology +12

Discovery of CGS 27023A, a Non-Peptidic, Potent, and Orally Active Stromelysin Inhibitor That Blocks Cartilage Degradation in Rabbits

Lawrence MacPherson, Erol K. Bayburt, Michael Capparelli et al. · Journal of Medicinal Chemistry · 1997 · 325 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

A Novel Synthesis of Dialkyl Arenephosphonates

Toshikazu Hirao, Toshio Masunaga, Yoshiki Ohshiro et al. · Synthesis · 1981 · 300 citations

Natural Sciences, Chemistry, Medicinal Chemistry +2

2,4-Dinitrobenzenesulfonamides: A simple and practical method for the preparation of a variety of secondary amines and diamines

Tohru Fukuyama, Mui Cheung, Chung-Kuang Jow et al. · Tetrahedron Letters · 1997 · 285 citations

Natural Sciences, Chemistry, Organic Chemistry +1