The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Anna Secher, Jacob Jelsing, Arian F. Baquero, +13

Journal of Clinical Investigation

Liraglutide UptakeGastrointestinal Peptide HormoneHypothalamic PeptideCell SignalingEnergy Homeostasis +15

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

Charles Pyke, R. Scott Heller, Rikke Kaae Kirk, +7

Endocrinology

Immunocytochemical TechniqueImmunologyCellular PhysiologyInsulin SignalingGastrointestinal Peptide Hormone +20

Semaglutide lowers body weight in rodents via distributed neural pathways

Sanaz Gabery, Casper G. Salinas, Sarah Juel Paulsen, +22

JCI Insight

Food IntakePharmacotherapyExperimental PharmacologyNeuromuscular BlockadeGastrointestinal Peptide Hormone +21

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

Leif R. Lund, John Rømer, Nicole Thomasset, +5

Development

ApoptosisImmunologyPathologyCell DeathApoptotic Cells +15

Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist

Stephen T. Buckley, Tine A. Bækdal, Andreas Vegge, +19

Science Translational Medicine

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

Charles Pyke, Peter Kristensen, J Grøndahl-Hansen, +3

PubMed

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

Charles Pyke, Pirkko Huhtala, T Hurskainen, +2

PubMed

EngineeringPathologyHuman Skin CancersDermatologyMessenger Rna +18

Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer.

Charles Pyke, Karl Tryggvason, Keld Danø

PubMed

The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers.

Charles Pyke, John Rømer, Pekka Kallunki, +3

PubMed

Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy

Mikkel W. Pedersen, Helle J. Jacobsen, Klaus Koefoed, +4

Cancer Research

Anti-egfr Monoclonal AntibodiesEgfr InternalizationImmunologySuperior Anticancer EfficacyImmune Checkpoint Inhibitor +10