Concepedia

Publication | Open Access

IL-24 Inhibits Lung Cancer Cell Migration and Invasion by Disrupting The SDF-1/CXCR4 Signaling Axis

DOIFull Paper Access

67

Citations

53

References

2015

Year

Janani Panneerselvam, Jiankang Jin, Manish Shanker, Jason Lauderdale, Jonathan Bates, Qi Wang, Yan D. Zhao, Stephen J. Archibald, Timothy J. Hubin, Rajagopal Ramesh
PLoS ONE

Abstract

IL-24 disrupts the SDF-1/CXCR4 signaling pathway and inhibits lung tumor cell migration and invasion. Additionally, IL-24, when combined with CXCR4 inhibitors exhibited enhanced anti-metastatic activity and is an attractive therapeutic strategy for lung metastasis.

References

YearCitations

Page 1